Nipam Patel

Over the past two decades, developmental biologists have made great strides in understanding embryonic pattern formation at the genetic, molecular, and cellular levels. Much of this advancement can be attributed to the remarkable success of studies of pattern formation in model systems, such as the fruit fly Drosophila melanogaster. Identification of genes that play major roles in setting up the body plan, combined with the subsequent discovery that many of these genes are well conserved even between different phyla, has also led to a renaissance in the investigation of the links between evolution and development. Using information collected from studies of Drosophila development, my lab and others are beginning to explore the degree to which developmental pathways have been conserved or altered between various arthropods. Insights into the nature of developmental and molecular alterations will help us to understand the evolutionary changes in the mechanisms of pattern formation and provide a molecular basis for analyzing the diversification of body morphologies and developmental mechanisms.

A Fenofibrate Diet Prevents Paclitaxel-Induced Peripheral Neuropathy in Mice.
Caillaud M, Patel NH, Toma W, White A, Thompson D, Mann J, Tran TH, Roberts JL, Poklis JL, Bigbee JW, Fang X, Gewirtz DA, Damaj MI. A Fenofibrate Diet Prevents Paclitaxel-Induced Peripheral Neuropathy in Mice. Cancers (Basel). 2020 Dec 29; 13(1).
PMID: 33383736

Knockout of crustacean leg patterning genes suggests that insect wings and body walls evolved from ancient leg segments.
Bruce HS, Patel NH. Knockout of crustacean leg patterning genes suggests that insect wings and body walls evolved from ancient leg segments. Nat Ecol Evol. 2020 Dec; 4(12):1703-1712.
PMID: 33262517

Triangular Relationship between p53, Autophagy, and Chemotherapy Resistance.
Xu J, Patel NH, Gewirtz DA. Triangular Relationship between p53, Autophagy, and Chemotherapy Resistance. Int J Mol Sci. 2020 Nov 26; 21(23).
PMID: 33256191

The Roles of Autophagy and Senescence in the Tumor Cell Response to Radiation.
Patel NH, Sohal SS, Manjili MH, Harrell JC, Gewirtz DA. The Roles of Autophagy and Senescence in the Tumor Cell Response to Radiation. Radiat Res. 2020 08 01; 194(2):103-115.
PMID: 32845995

Structural color in Junonia butterflies evolves by tuning scale lamina thickness.
Thayer RC, Allen FI, Patel NH. Structural color in Junonia butterflies evolves by tuning scale lamina thickness. Elife. 2020 Apr 07; 9.
PMID: 32254023

Influence of nonprotective autophagy and the autophagic switch on sensitivity to cisplatin in non-small cell lung cancer cells.
Patel NH, Xu J, Saleh T, Wu Y, Lima S, Gewirtz DA. Influence of nonprotective autophagy and the autophagic switch on sensitivity to cisplatin in non-small cell lung cancer cells. Biochem Pharmacol. 2020 05; 175:113896.
PMID: 32135156

Studies of Non-Protective Autophagy Provide Evidence that Recovery from Therapy-Induced Senescence is Independent of Early Autophagy.
Saleh T, Tyutyunyk-Massey L, Patel NH, Cudjoe EK, Alotaibi M, Gewirtz DA. Studies of Non-Protective Autophagy Provide Evidence that Recovery from Therapy-Induced Senescence is Independent of Early Autophagy. Int J Mol Sci. 2020 02 20; 21(4).
PMID: 32093197

The amphipod crustacean Parhyale hawaiensis: An emerging comparative model of arthropod development, evolution, and regeneration.
Sun DA, Patel NH. The amphipod crustacean Parhyale hawaiensis: An emerging comparative model of arthropod development, evolution, and regeneration. Wiley Interdiscip Rev Dev Biol. 2019 09; 8(5):e355.
PMID: 31183976

Nanopore sequencing of long ribosomal DNA amplicons enables portable and simple biodiversity assessments with high phylogenetic resolution across broad taxonomic scale.
Krehenwinkel H, Pomerantz A, Henderson JB, Kennedy SR, Lim JY, Swamy V, Shoobridge JD, Graham N, Patel NH, Gillespie RG, Prost S. Nanopore sequencing of long ribosomal DNA amplicons enables portable and simple biodiversity assessments with high phylogenetic resolution across broad taxonomic scale. Gigascience. 2019 05 01; 8(5).
PMID: 30824940

Gallium, neon and helium focused ion beam milling of thin films demonstrated for polymeric materials: study of implantation artifacts.
Allen FI, Velez NR, Thayer RC, Patel NH, Jones MA, Meyers GF, Minor AM. Gallium, neon and helium focused ion beam milling of thin films demonstrated for polymeric materials: study of implantation artifacts. Nanoscale. 2019 Jan 17; 11(3):1403-1409.
PMID: 30604814

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